The Argentine named a surprisingly strong starting XI in the previous round against AFC Wimbledon, but it paid off with Spurs running out comfortable 3-0 winners at Wembley.
Pochettino may choose to do so again at Rodney Parade, although with a midweek round of Premier League fixtures it's more likely he makes changes to his side.
Our unique algorithm has predicted the Tottenham side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game.You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.