Defeat, coupled with a win for Inter against PSV, would leave Spurs six points adrift. It would be a difficult gap to make up, hence why it's imperative Mauricio Pochettino's men take something from the game.
The good news is that Tottenham have played their way back into form and Harry Kane is in the goals; the England striker netted a brace against Huddersfield Town at the weekend.
Our unique algorithm has predicted the Tottenham side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, and the statistical likelihood of a player being selected. The widget can also show you players' recent form and stats.