The Gabonese has starred for the Saints since his summer move from Juventus but has been ruled out of Saturday's fixture against the Clarets with an ankle injury.
Lemina joins full-back Jeremy Pied on the sidelines for the Southampton. But there is better news on striker Charlie Austin who has recovered from a knock which ruled him out against Brighton & Hove Albion last weekend.
Pellegrino changed shape slightly for the trip to Amex, setting his side up in a 4-1-4-1 system, but could revert to the 4-3-1-2 which he had previously utilised with Lemina set to miss out.
Our unique algorithm has predicted the Saints side it believes is most likely to start, but you can also give it a go yourself.
Just click ‘create your own’ on the lineup at the top of the page and pick the XI players you would choose, and you can also see their stats per 90 minutes once you’ve picked them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.