Both sides were victorious last weekend with the Seagulls enjoying a crushing 3-0 victory at West Ham United to claim their first win away from the Amex Stadium in the Premier League.
Southampton, meanwhile, were not quite as convincing in their 1-0 triumph over West Bromwich Albion at St Mary's – a stunning individual goal from Sofiane Boufal minutes after his introduction from the bench settled an otherwise drab tie.
Whether the Moroccan will be rewarded with a start against Brighton is the big selection decision for Mauricio Pellegrino. The 24-year-old celebrated vociferously in front of his coach – further reinforcing his point – but has flattered to deceive since arriving from Lille in August 2016.
He could take the place of Dušan Tadić at No.10 with Pellegrino shifting to a 4-4-2 diamond for the Baggies' visit. The other big call for the Argentine will be over who to start up front. Shane Long got the nod alongside Manolo Gabbiadini last weekend but Charlie Austin is also waiting in the wings.
Full-back Jeremy Pied (knock) is the only absentee for the Saints, giving Pellegrino a near clean bill of health to work with.
Our unique algorithm has predicted the Saints side it believes is most likely to start, but you can also give it a go yourself.
Just click ‘create your own’ on the lineup at the top of the page and pick the XI players you would choose, and you can also see their stats per 90 minutes once you’ve picked them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.