Southampton have had a week to forget. Tottenham and Harry Kane picked them apart on Boxing Day and when it seemed things couldn't get any worse, Virgil Van Dijk's inevitable transfer to Liverpool has been announced, and now they travel to Old Trafford.
Currently 14th in the table, the Saints have taken 19 points from 20 games this season. United, meanwhile, are in 2nd place after claiming 43 points from their 20 matches.
Our unique algorithm has predicted the Southampton side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game.You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.