La Roja saw their preparation thrown into disarray when it was announced coach Julen Lopetegui would succeed Zinedine Zidane as Real Madrid boss, a move which saw the Spanish football association sack the 51-year-old for failing to disclose the fact he had opened negotiations with the Champions League winners.
Former Los Blancos player Fernando Hierro has stepped into the breach and as starts go, facing Cristiano Ronaldo and co. in Spain's Group B opener is far from ideal.
If Portugal are to advance as Group B winners then overcoming the 2010 World Cup winners will be the perfect start.
Our unique algorithm has predicted the Portugal side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game. You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.