Currently 14th in the Premier League, the Eagles have taken 17 points from 18 games this season despite a disastrous start to the campaign under former manager Frank de Boer.
The Swans, meanwhile, are bottom of the table and this week sacked manager Paul Clement. Swansea were hoping to appoint a new boss ahead of the contest, however, with Tony Pulis the bookies' favourite.
Our unique algorithm has predicted the Crystal Palace side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game.You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.