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José Mourinho's side were dumped out of the Champions League on Tuesday evening by unfancied Sevilla, leaving the FA Cup as their only chance of silverware this season.
Standing between the Red Devils and the semi-finals are surprise package Brighton. Chris Hughton's men have grown into this Premier League campaign and find themselves 11th, comfortably in mid-table and seven points above the relegation zone.
United boss Mourinho will be without Ander Herrera (hamstring), Marcus Rojo (knock), Phil Jones (knock), Daley Blind (ankle) and Zlatan Ibrahimović (knee).
Our unique algorithm has predicted the Manchester United side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game.You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.