The Red Devils are on a ten-game unbeaten run against the Gunners at Old Trafford. However, this is Wenger's last trip to the Theatre of Dreams, the scene of the Gunners' 2002 title victory, as well as an 8-2 defeat in 2011 and the end of the Invincibles' 49-game unbeaten run.
Opposite number Mourinho will be full of confidence after his side put away the other team from North London last weekend in the FA Cup semi-final at Wembley.
Our unique algorithm has predicted the Manchester United side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game.You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.