Pep Guardiola will be looking to get back to winning ways and it would take a monumental performance from Rafa Benítez's side to stop the champions.
Kevin De Bruyne continues to miss out with a knee injury, while Danilo is still out with an ankle problem.
City went to a back four away at Wolves, but they are expected to return to 3-5-2, with Sergio Agüero and Gabriel Jesus up front for the home match.
Our unique algorithm has predicted the City side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game.You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.