The Red Devils currently occupy second position, trailing runaway leaders Manchester City and just two points above the Reds.
After a dramatic come-from-behind victory over Crystal Palace at Selhurst Park on Monday night, José Mourinho's men with be hoping for a less eventful afternoon at Old Trafford.
United currently have seven players listed as injured: Ander Herrera, Phil Jones, Marcos Rojo, Marouane Fellaini, Daley Blind and Zlatan Ibrahimović are all ruled out, while Anthony Martial is a slight doubt.
Eric Bailly, fit again after a three-month layoff, will be in contention to start, while Marcus Rashford's impressive cameo against the Eagles will have brought him back into Mourinho's thinking ahead of one of United's biggest games of the season.
After breaking his big-game duck against Chelsea two weeks ago, Romelu Lukaku will be the Red Devils' danger man. But Mourinho will want more from January signing Alexis Sánchez, who struggled against Palace.
Our unique algorithm has predicted the United side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game.You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press ‘confirm' and you’ll be able to share it with your friends via social media.