Having struggled in recent weeks with a shock UEFA Champions League exit at the hands of Sevilla and a less than impressive display against Brighton & Hove Albion, José Mourinho's men will be hoping the international break will provide a change in fortune for the Red Devils.
Since the United last played, Zlatan Ibrahimović has since left the club for LA Galaxy following the termination of his contract.
Facing a seemingly impossible task of bringing the Premier League trophy to the red side of Manchester, Mourinho's men will be focusing their efforts on finishing both second and winning the FA Cup.
Our unique algorithm has predicted the Manchester United side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game.You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.