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Going into the game, Jürgen Klopp’s side are top of Group E and are three points clear of the Spanish side, who sit in second.
The match between them at Anfield ended in a 2-2 draw, and Liverpool have never previously beaten Sevilla, losing their only other previous encounter, the 2016 Europa League final.
And that means if the Spanish side win tonight, they’ll move ahead of the Reds due to their head-to-head record.
Liverpool only have one injury problem, with Joël Matip not travelling to Spain after missing the win over Southampton on Saturday with a thigh injury.
There is also talk that Gini Wijnaldum could be rested ahead of Saturday’s Premier League clash with Chelsea.
Kick-off at the Ramon Sánchez Pizjuan is at 7.45pm and UK viewers can watch the game on BT Sport.
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