Antonio Conte’s side only met Saints last weekend, coming from 2-0 down to win 3-2 thanks to an impressive cameo off the bench from Olivier Giroud, who scored twice.
That match saw Eden Hazard and Willian rested. Expect them to return to the starting lineup.
The Blues will be without Marcos Alonso though, who’s in the middle of serving a three-match ban after a challenge on Shane Long last weekend. That will mean Emerson is likely to come in, although Conte could opt to play Davide Zappacosta there instead.
Our unique algorithm has predicted the Chelsea side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
You can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game. You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press ‘confirm' and you’ll be able to share it with your friends via social media.