Sarri's side are yet to taste defeat in competitive action under the Italian, a run that now stretches 11 matches across all competitions.
Having rested several players for the midweek Europa League win over MOL Vidi, Chelsea are likely to be back to full strength against the Saints.
Our unique algorithm has predicted the Chelsea side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, and the statistical likelihood of a player being selected. The widget can also show you players’ recent form and stats.