Chris Hughton and his men will be aware that they could face some sort of backlash after the North Londoners were picked apart by Manchester City at Wembley on Saturday.
The Seagulls, meanwhile, were beaten 3-2 by rivals Crystal Palace on Saturday and will look to build on their impressive home record against Mauricio Pochettino's.
Our unique algorithm has predicted the Brighton side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game.You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.