It's been a difficult season for Saints. They've struggled for goals under Mauricio Pellegrino and are currently in the relegation zone in the Premier League.
However, while results have been disappointing, that hasn't always been down to poor performances. Who can forget the game against Watford a fortnight ago that ended in a 2-2 draw after Abdoulaye Doucouré handled the ball home in the dying minutes.
Southampton will be looking to avenge that results at St Mary's and our unique algorithm has predicted the Saints side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game. You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.