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Spurs' win over Liverpool moved them level on 20 points with United after José Mourinho‘s side slumped to their first league defeat of the season against Huddersfield Town.
Wednesday night's Carabao Cup defeat to West Ham United is unlikely to have a major bearing on this game so, with momentum in their favour, Pochettino will hope to clinch a victory at Old Trafford and move ahead of United into second place.
Harry Kane is ruled out after picking up a hamstring strain against Liverpool, which is a major blow for Pochettino, so Fernando Llorente should deputise.
Mousa Dembélé's return to first-team action against the Hammers came as a major boost and the powerful Belgian midfielder may miss out to Harry Winks.
Our unique algorithm has predicted the Tottenham side it believes is most likely to start.
Football Whispers uses data to predict the starting line-ups for sides by accounting for a number of different factors, including injuries, suspensions, the statistical likelihood to play, the match the competition is played, the player’s previous performance and the style of the opposition.
But you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick the XI players you would choose, and you can also see their stats once you’ve picked them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.