Mauricio Pochettino’s side counted themselves unlucky to lose 4-2 to Chelsea in their FA Cup semi-final at Wembley, but the manager knows his players must bounce back in a tricky midweek fixture against an Eagles team bristling with confidence after beating Liverpool at Anfield.
However, Spurs are hoping to make it eight straight league wins here and have beaten Palace in each of their last three meetings, so the odds are heavily in their favour.
Sam Allardyce’s men only need one more win to mathematically guarantee their safety, though, so they are likely to take the game to their London rivals.
Pochettino is likely to make changes after starting Son Heung-Min as a makeshift left wing-back backfired against Chelsea.
Ben Davies is likely to be recalled into the starting line-up with the South Korean dropped to the bench.
On the opposite flank, Kyle Walker is expected to start ahead of Kieran Trippier, even though speculation has intensified over his future this week.
Walker’s pace will be key in stopping Palace’s speedy wide men enjoying further joy after their victory over Liverpool.
Mousa Dembélé and Victor Wanyama will continue their formidable midfield partnership in an attempt to prevent Palace’s players finding Christian Benteke in attack.
Up top for Spurs, Dele Alli will be in particularly high spirits after being named PFA Young Player of the Year for the second year running, while Harry Kane has scored 20 goals in his last 21 games while Christian Eriksen has notched 11 assists and four goals in his last 11 appearances, including two on Saturday against Chelsea.