David Wagner's side are 11th in the Premier League table after three wins, three draws and three defeats from their opening nine games.
And it will be a fascinating case of the mentor taking on the apprentice as Wagner faces Jürgen Klopp, the long-time friend who offered him the chance to coach the Borussia Dortmund reserve team.
Wagner, who was the best man at Klopp's wedding, will be keen to get one over on his compatriot, who is coming off a humbling defeat to Tottenham Hotspur last week.
With no fresh injury concerns, Wagner is likely to stick with the same team who downed United at the John Smith's Stadium last week.
That will mean a back four of Tom Smith, Mathias Jørgensen, Christopher Schindler and Chris Löwe. Jonathan Hogg will provide protection as the holding midfielder in front of the defence.
If there are any changes, Wagner may choose to go with Rajiv Van La Parra ahead of Elias Kachunga. The former replaced the latter after 39 minutes during the win over United and impressed, which could see him retain his place.
Our unique algorithm has predicted the Huddersfield side it believes is most likely to start.
Football Whispers uses data to predict the starting line-ups for sides by accounting for a number of different factors, including injuries, suspensions, the statistical likelihood to play, the match the competition is played, the player’s previous performance and the style of the opposition.
But you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick the XI players you would choose, and you can also see their stats once you’ve picked them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.