It was at Merseyside in this fixture last season where the Gunners were downed 2-1 by the Toffees. With Ronald Koeman struggling with just two wins from eight games, this could be one of the easiest trips the North London club have ever made to the North West.
Arsenal will want to bounce back from their 2-1 defeat to Watford last Saturday and that started with the tough late win away at Red Star Belgrade.
Arsène Wenger will have a number of personnel issues to deal with. Goals have been hard to come by, but Olivier Giroud showed once again that when his club needs him he can step up and be counted.
Jack Wilshere, Theo Walcott and Mohamed Elneny all played their part in the Gunners midweek win, but a number of first-team regulars will be handed their spots back in the XI, it just depends on who the French coach gives the nod.
In the middle, everyone will expect Granit Xhaka to return, but the place as his partner is up for grabs.
An away trip to Goodison might be a big ask for Wilshere, but if he can handle Belgrade, anything is possible.
Upfront, Alexandre Lacazette will be recalled, but he could play to the side of Giroud and Walcott if Wenger wants to mix things up.
Mesut Özil would be ideal in this type of scenario, as discussed in this column, he has created a number of good chances for the Gunners this season despite the criticism over his performances.
This could be the ideal time to play Lacazette, Özil and Alexis Sánchez upfront together.
Our unique algorithm has predicted the Arsenal side it believes is most likely to start, but you can also give it a go yourself.
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