Winning the title without even kicking a ball, Pep Guardiola's men dispatched Swansea City 5-0 to celebrate last weekend.
With nothing else to play for, the Manchester club may look to rotate their side, but regardless of who plays, it will be a strong XI against the Hammers.
David Moyes knows that, with his team sitting six points above the relegation zone, another three points could be enough to secure their Premier League status.
Benjamin Mendy will be favourite to start at left-back after making his long-awaited return from injury.
Our unique algorithm has predicted the Man City side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game.You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.