Under the shrewd management of Rafael Benítez, the North East outfit have overcome defeats to Tottenham Hotspur and Huddersfield Town in their first two fixtures and are fourth thanks to a run of three consecutive victories.
Meanwhile, Brighton, who are managed by ex-Magpies boss Chris Hughton, have tasted victory just once since promotion as they struggle for goals but find themselves just above the relegation zone in 16th.
Benítez only has three injuries to contend with, giving him an almost fully-fit squad to choose from for United's trip to the AmEx Stadium.
Goalkeeper Karl Darlow (ankle) could be fit in time but Benítez appears to have made Rob Elliot his No.1 this season.
Defensive duo Paul Dummett (hamstring) and Massadio Haidara (knee) are both sidelined with medium-term injuries.
Use our predicted line-ups feature at the top of the page to pick and share the side you would pick if you were Benítez on Sunday.
Our unique algorithm has predicted the starting XI it believes is most likely to start, but you can also give it a go yourself.
Just click “create your own” on the lineup at the top of the page and pick the XI players you would choose, and you can also see their stats per 90 minutes once you’ve picked them.
When you’re happy with your team, press confirm and you’ll be able to share it wth your friends via social media.