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Spurs go into the game on the back of consecutive defeats to Burnley and Chelsea respectively. Arsenal, meanwhile, cruised to a comprehensive victory over Bournemouth in midweek.
There will be far more at stake than just local bragging rights, though. The match could go a long way to deciding both clubs' Premier League top four ambitions.
Tottenham are currently third in the table, having taken 60 points from their 28 league games. Arsenal sit below them, four points behind. The Gunners will be desperate to close that gap – Chelsea and Manchester United could also then move to within touching distance of Mauricio Pochettino's side.
Both sides have injuries but there will still be plenty of quality on show at English football's national stadium. And with that in mind, we have picked our North London derby combined XI, one which has been selected on form rather than reputation.
Let us know what you think of the team in the video above by tweeting us @FB_Whispers.